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Chlorothiazide Structure

Product Type

Active Pharmaceutical Ingredient (API)

Grade

USP / BP / EP (as applicable)

Chemical Formula

C₇H₆ClN₃O₄S₂

Molecular Weight

295.72 g/mol

CAS Number

58-94-6

IUPAC Name

6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Chemical Class

Thiazide diuretic (benzothiadiazine derivative)

Therapeutic Class

Diuretic & antihypertensive agent for edema, hypertension & fluid overload

Synonyms

PHYSIOCHEMICAL PROPERTIES

Appearance White to off-white crystalline powder
Solubility Slightly soluble in water; soluble in alkaline solutions; sparingly soluble in alcohol; practically insoluble in most organic solvents
Melting Point ~355–360°C
pH ~5.5 – 7.0

Product Description

Chlorothiazide is a first-generation thiazide diuretic widely used in the management of hypertension, edema, congestive heart failure, and renal disorders. It works by blocking sodium reabsorption in the distal convoluted tubule, resulting in increased urine output and reduced plasma volume.

How Chlorothiazide Works

Chlorothiazide acts on the distal convoluted tubule of the nephron by: Inhibiting Na⁺/Cl⁻ symporter → reduces sodium & chloride reabsorption, Increasing urinary excretion of Na⁺, Cl⁻, and water → diuresis. Overall, it provides antihypertensive and anti-edema activity.

Use(s)

Adverse Effects

Why choose Salius for Chlorothiazide?

  1. Regulatory-Grade Manufacturing Standards
    They maintain WHO GMP compliance, with some facilities FDA certified, and follow stringent internal QC protocols. Every batch is tested in state-of-the-art labs before release.
  2. Enhancing Cost-Effectiveness Through Large Volume API Utilization
    As an exporter and distributor house, Salius aims to deliver high-quality APIs at competitive prices, a key advantage for cost-sensitive markets.
  3. Global Export Experience & Documentation Support
    Salius regularly exports APIs, provides regulatory documents (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets.
  4. Documents We Provide
  5. Transparency & Trustworthiness
    They present as a government-recognized star export house with strong quality and delivery ratings.
Attribute Why Salius Pharma Is a Good Choice
Quality Certification WHO GMP, ISO 9001:2015, FDA audited facilities
Affordability & Generic Access Cost competitive generics for global supply
Export Experience Proven track record of supplying globally

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.

FAQs

Yes — Open Part DMF / CTD format can be provided for regulated or semi-regulated markets.

250 mg / 500 mg Tablets, 250 mg/5 mL Oral Suspension, 500 mg Injection (lyophilized).

Residual solvents are controlled as per ICH Q3C. Heavy metals & elemental impurities comply with ICH Q3D.

Store at 25°C, protected from excessive moisture & light.

Yes — triple-layer liners, alu-pouches, moisture absorbers, or nitrogen-flushed drums.

Place an Order or Request a Quote from Salius Pharma

Looking to source Chlorothiazide or other high-quality pharmaceutical products?
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Whether you need Active Pharmaceutical Ingredients (APIs), finished formulations, or regulatory support, our team is ready to provide dependable, compliant, and cost-effective solutions tailored to your market needs.

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