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Doxylamine Succinate Structure

Product Type

Active Pharmaceutical Ingredient (API)

Grade

BP / USP / EP (as applicable)

Chemical Name

Doxylamine Succinate

Chemical Formula

C₁₇H₂₂N₂O·C₄H₆O₄

Molecular Weight

~388.46 g/mol

CAS Number

562-10-7

IUPAC Name

N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine hydrogen succinate

Chemical Class

First-generation ethanolamine antihistamine

Synonyms

PHYSIOCHEMICAL PROPERTIES

Appearance White to off-white crystalline powder
Solubility Freely soluble in water & alcohol; slightly soluble in chloroform
Melting Point 107–111°C
pH 5.0 – 6.0

Product Description

Doxylamine Succinate is a first-generation antihistamine from the ethanolamine class with pronounced sedative properties. It is widely used globally in OTC formulations for allergic symptoms, insomnia, and as a night-time analgesic combination component.

How Doxylamine Succinate Works

It acts in the following 3 ways:
1. H₁-receptor antagonist: Blocks histamine H₁ receptors → reduces allergic symptoms.
2. Anticholinergic action: Mild M₁ receptor blockade contributes to sedative and antiemetic effects.
3. CNS depressant: Strong central histamine blockade → sleep-inducing properties.

Use(s)

Adverse Effects

Why choose Salius for Doxylamine Succinate?

  1. Regulatory-Grade Manufacturing Standards
    They maintain WHO GMP compliance, with some facilities FDA certified, and follow stringent internal QC protocols. Every batch is tested in state-of-the-art labs before release
  2. Enhancing Cost-Effectiveness Through Large Volume API Utilization
    As an exporter and distributor house, Salius aims to deliver high-quality APIs at competitive prices, a key advantage for cost-sensitive markets.
  3. Global Export Experience & Documentation Support
    Salius regularly exports APIs, provides regulatory documents (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets.
  4. Documents We Provide
  5. Transparency & Trustworthiness
    They present as a government-recognized star export house with strong quality and delivery ratings.
Attribute Why Salius Pharma Is a Good Choice
Quality Certification WHO GMP, ISO 9001:2015, FDA audited facilities
Affordability & Generic Access Cost competitive generics for global supply
Export Experience Proven track record of supplying globally

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.

FAQs

Yes, Doxylamine Succinate is compatible with common excipients such as lactose, MCC, and starch. Mild hygroscopicity requires avoiding very high-moisture excipients.

Generally, wet granulation is preferred for uniformity and better flow. Direct compression is possible with optimized PSD and flow aids.

It is stable between pH 4.5–6.0. Liquid formulations typically target pH 5.0–5.5.

Not required as the API isn’t oxygen-sensitive. However, nitrogen flushing can be provided if requested.

No, it is shipped as non-hazardous, non-dangerous goods under IATA/IMDG/ADR.

Place an Order or Request a Quote from Salius Pharma

Looking to source Doxylamine Succinate or other high-quality pharmaceutical products?
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Whether you need Active Pharmaceutical Ingredients (APIs), finished formulations, or regulatory support, our team is ready to provide dependable, compliant, and cost-effective solutions tailored to your market needs.

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