API's
Active Pharmaceutical Ingredients
Active Pharmaceutical Ingredients
Active Pharmaceutical Ingredient (API)
USP / BP / EP (as applicable)
Indinavir sulfate
C₃₆H₄₇N₅O₄ · H₂SO₄
711.87 g/mol
157810-81-6
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2 hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxo pentyl] N tert butyl 4-(pyridin-3-ylmethyl)piperazine-2-carboxamide; sulfate
Antiviral — HIV 1 protease inhibitor
Antiretroviral
| Appearance | White to off white, hygroscopic, crystalline powder |
|---|---|
| Solubility | Very soluble in water and methanol; soluble in water for stock solutions |
| Melting Point | 150–153°C (decomposition) |
| pH | - |
Indinavir sulfate is a potent antiretroviral drug belonging to the HIV 1 protease inhibitor class. As a sulfate salt, it is formulated for oral use, with good bioavailability when properly administered. Its mechanism targets the viral protease enzyme — an essential component in the HIV life cycle — thereby preventing the maturation of viral polyproteins and blocking production of infectious viral particles. As a result, Indinavir suppresses viral replication and reduces HIV viral load in infected individuals.
Indinavir binds selectively and potently to the active site of HIV 1 protease, inhibiting its enzymatic activity. By inhibiting the protease, Indinavir prevents the cleavage of viral gag pol polyproteins — a critical step required to produce mature, infectious virions. As a result, the virus produces immature, non infectious particles, halting further infection cycles.
| Attribute | Why Salius Pharma Is a Good Choice |
|---|---|
| Quality Certification | WHO GMP, ISO 9001:2015, FDA audited facilities |
| Affordability & Generic Access | Cost competitive generics for global supply |
| Export Experience | Proven track record of supplying globally |
When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.
We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.
7 to 21 business days from dispatch, depending on your location.
The melting point is approximately 150–153°C with decomposition. It is crystalline and sensitive to heat. Proper storage prevents degradation.
Yes, it is mainly formulated as oral capsules. Used in combination antiretroviral therapy (HAART). Bioavailability is optimized in the sulfate salt form.
Both wet granulation and direct compression are suitable. Micronized API improves uniformity and dissolution. Processing must control polymorphic and hygroscopic properties.
Yes, Indinavir sulfate can exist in different polymorphic forms. Polymorph control is important for consistent bioavailability. Processing and storage conditions affect stability.
Yes, manufactured under full cGMP compliance. Validated processes and QC ensure high-quality API. Documentation is provided for regulatory and export purposes.
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