Irinotecan HCl Trihydrate

Synonyms

• Irinotecan HCl Trihydrate, CPT-11, Camptosar®, Onivyde®, (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl-[1,4′-bipiperidine]-1′-carboxylate hydrochloride trihydrate

PHYSIOCHEMICAL PROPERTIES

Product Description

Irinotecan HCl Trihydrate is a semisynthetic camptothecin derivative used as a chemotherapy agent primarily for treating metastatic colorectal cancer and other solid tumors. It works by inhibiting topoisomerase I, an enzyme essential for DNA replication, leading to DNA damage and cancer cell death.

How Irinotecan HCl Trihydrate Works

Irinotecan Hydrochloride Trihydrate works by inhibiting the enzyme topoisomerase I, which is crucial for relieving DNA supercoiling during replication. By stabilizing the complex between topoisomerase I and DNA, irinotecan prevents the re-ligation (repair) of single-strand DNA breaks. This leads to the accumulation of DNA damage, ultimately causing cancer cell death through apoptosis. This mechanism makes irinotecan effective in stopping the growth of rapidly dividing cancer cells.

Use(s)

• Irinotecan Hydrochloride Trihydrate is primarily used to treat metastatic colorectal cancer and small-cell lung cancer, often in combination with other chemotherapy agents. It may also be used for other solid tumors as prescribed by oncologists.

Adverse Effects

• Diarrhea (early and late onset)
• Nausea and vomiting
• Neutropenia (low white blood cell count)
• Anemia
• Thrombocytopenia (low platelet count)
• Fatigue and weakness
• Alopecia (hair loss)

Why choose Salius for Irinotecan HCl Trihydrate?

1. WHO-GMP Certified Manufacturing
   Salius Pharma produces Irinotecan HCl Trihydrate in facilities certified by the World Health Organization’s Good Manufacturing Practices (WHO-GMP), ensuring the API meets high-quality, safety, and purity standards required globally.
2. Consistent Quality and Reliability
   They maintain strict quality control protocols to provide consistent, pharmaceutical-grade Irinotecan HCl Trihydrate. This reliability helps pharmaceutical companies avoid batch failures and regulatory issues.
3. Global Export Experience & Documentation Support
   Salius regularly exports APIs, provides regulatory documents (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets.

4. Focus on Chronic Therapy APIs
   Salius specializes in APIs for chronic diseases, demonstrating expertise in producing reliable compounds like Irinotecan HCl Trihydrate, often used in long-term treatments.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Irinotecan HCl Trihydrate
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.