Leflunomide

Synonyms

• LEF, 5-Methyl-N-[4-(trifluoromethyl)phenyl]-isoxazole-4-carboxamide

PHYSIOCHEMICAL PROPERTIES

Product Description

Leflunomide is an immunomodulatory and anti-inflammatory agent used primarily to treat rheumatoid arthritis and other autoimmune conditions. It works by inhibiting dihydroorotate dehydrogenase (DHODH), a key enzyme in pyrimidine synthesis, which reduces the proliferation of activated lymphocytes. Leflunomide is orally active, has good bioavailability, and is often used as a long-term disease-modifying therapy.

How Leflunomide Works

Leflunomide works by inhibiting dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway, which reduces the proliferation of activated T- and B-lymphocytes. This action provides significant anti-inflammatory effects and helps modulate autoimmune responses, while exhibiting minimal direct cytotoxicity to other human cells at therapeutic doses.

Use(s)

• Rheumatoid arthritis
• Psoriatic arthritis

Adverse Effects

• Diarrhea
• Nausea
• Alopecia
• Rash

Why choose Salius for Leflunomide?

1. Regulatory-Grade Manufacturing Standards
   They maintain WHO GMP compliance, with some facilities FDA certified, and follow stringent internal QC protocols. Every batch is tested in state-of-the-art labs before release
2. Enhancing Cost-Effectiveness Through Large Volume API Utilization
   As an exporter and distributor house, Salius aims to deliver high-quality APIs at competitive prices, a key advantage for cost-sensitive markets.
3. Global Export Experience & Documentation Support
   Salius regularly exports APIs, provides regulatory documents (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets.

4. Transparency & Trustworthiness
   They present as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Leflunomide
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.