Loperamide HCl

Synonyms

• Loperamide HCl, Loperamide Monohydrochloride, Imodium (brand name), 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride, Loperamide hydrochloride monohydrate

PHYSIOCHEMICAL PROPERTIES

Product Description

Loperamide HCl is a synthetic antidiarrheal agent classified as a piperidine derivative. It works by acting on μ-opioid receptors in the intestinal wall to reduce peristalsis and prolong transit time, allowing more water and electrolytes to be absorbed. Unlike other opioids, it does not significantly cross the blood-brain barrier, so it lacks central nervous system effects at therapeutic doses. Loperamide is commonly used to treat acute and chronic diarrhea, including traveler’s diarrhea and diarrhea associated with irritable bowel syndrome (IBS). It is widely known under the brand name Imodium and is available in various oral dosage forms. Its efficacy and low risk of central opioid side effects make it a first-line agent for symptomatic diarrhea control.

How Loperamide HCl Works

Loperamide Hydrochloride works by activating opioid receptors (specifically μ-opioid receptors) in the intestinal wall, which slows down intestinal motility (peristalsis). This slower movement allows more time for water and electrolytes to be absorbed back into the body, resulting in firmer stools and reduced frequency of diarrhea. Importantly, loperamide acts mostly locally in the gut and does not cross the blood-brain barrier significantly, so it doesn’t cause central opioid effects like pain relief or addiction at normal doses.

Use(s)

• Loperamide hydrochloride is used to treat acute and chronic diarrhea by reducing intestinal motility and improving stool consistency.

Adverse Effects

• Constipation
• Dizziness
• Abdominal cramps or pain
• Nausea
• Dry mouth
• Fatigue

Why choose Salius for Loperamide HCl?

1. WHO-GMP Certified Manufacturing
   Salius Pharma produces Loperamide HCl in facilities certified by the World Health Organization’s Good Manufacturing Practices (WHO-GMP), ensuring the API meets high-quality, safety, and purity standards required globally.
2. Consistent Quality and Reliability
   They maintain strict quality control protocols to provide consistent, pharmaceutical-grade Loperamide HCl. This reliability helps pharmaceutical companies avoid batch failures and regulatory issues.
3. Global Export Experience & Documentation Support
   Salius regularly exports APIs, provides regulatory documents (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets.

4. Focus on Chronic Therapy APIs
   Salius specializes in APIs for chronic diseases, demonstrating expertise in producing reliable compounds like Loperamide HCl, often used in long-term treatments.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Loperamide HCl
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.