Methotrexate

Synonyms

• Amethopterin, Methotrexate BP / USP, MTX

PHYSIOCHEMICAL PROPERTIES

Product Description

Methotrexate is a widely used antimetabolite and antifolate agent indicated for the treatment of various cancers and autoimmune disorders. It inhibits dihydrofolate reductase, thereby interfering with DNA synthesis, repair, and cellular replication.

How Methotrexate Works

Methotrexate competitively inhibits the enzyme dihydrofolate reductase (DHFR), leading to reduced formation of tetrahydrofolate. This results in impaired synthesis of thymidylate and purine nucleotides, ultimately inhibiting DNA and RNA synthesis. Rapidly dividing cells, such as cancer cells and activated immune cells, are particularly affected.

Use(s)

• Treatment of cancers (leukemia, lymphoma, osteosarcoma, breast cancer)
• Rheumatoid arthritis
• Psoriasis
• Ectopic pregnancy
• Autoimmune and inflammatory disorders

Adverse Effects

• Nausea and vomiting
• Mouth ulcers (stomatitis)
• Bone marrow suppression
• Hepatotoxicity
• Fatigue
• Hair loss
• Increased risk of infections

Why choose Salius for Methotrexate?

1. Regulatory-Grade Manufacturing Standards
   They maintain stringent WHO GMP standards, with some facilities FDA certified, and follows strict internal QC protocols. Every batch is tested in state-of-the-art labs before release, to ensure consistent quality, safety & efficacy
2. Cost-Effectiveness
   As a generic manufacturer and export house, Salius aims to deliver high-quality APIs at competitive prices—a key advantage for cost-sensitive and emerging markets.
3. Global Export Experience & Documentation Support
   Salius regularly exports APIs, provides regulatory dossiers (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets

4. Transparency & Trustworthiness
   They present as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Methotrexate
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.