Topotecan Hydrochloride

Synonyms

• Topotecan HCl, Hycamtin® API (reference), Topotecan Hydrochloride API

PHYSIOCHEMICAL PROPERTIES

Product Description

Topotecan Hydrochloride is a semi-synthetic camptothecin derivative used as an anticancer agent. It inhibits DNA topoisomerase I, leading to DNA damage and apoptosis in rapidly dividing tumor cells.

How Topotecan Hydrochloride Works

Topotecan selectively inhibits topoisomerase I by stabilizing the cleavable complex between the enzyme and DNA. This prevents DNA religation during replication, resulting in single-strand DNA breaks that trigger cell death, particularly in proliferating cancer cells.

Use(s)

• Treatment of metastatic ovarian cancer after failure of first-line therapy
• Treatment of small cell lung cancer (SCLC)
• Treatment of recurrent cervical cancer (in combination regimens)
• Ongoing oncology research applications

Adverse Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Diarrhea
• Fatigue
• Alopecia
• Increased risk of infection

Why choose Salius for Topotecan Hydrochloride?

1. Regulatory-Grade Manufacturing Standards
   They maintain WHO GMP compliance, with some facilities FDA certified, and follow stringent internal QC protocols. Every batch is tested in state-of-the-art labs before release
2. Cost-Effectiveness
   As a generic manufacturer and export house, Salius aims to deliver high-quality APIs at competitive prices—a key advantage for cost-sensitive markets.
3. Global Export Experience & Documentation Support
   Salius regularly exports APIs, provides regulatory dossiers (DMF, impurity profiles), and supports filings for international clients—even in stringent regulated markets

4. Transparency & Trustworthiness
   They present as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Topotecan Hydrochloride
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.