Valsartan & Hydrochlorothiazide DC Granules

Product Overview

Valsartan & Hydrochlorothiazide DC Granules are ready-to-compress pharmaceutical intermediates designed for the direct compression of fixed-dose combination antihypertensive tablets. These granules are pre-formulated with functional excipients to ensure excellent flowability, compressibility, and content uniformity—making them ideal for high-speed, large-scale tablet manufacturing. The combination of Valsartan, an angiotensin II receptor blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic, provides a synergistic effect in managing high blood pressure and reducing cardiovascular risk.

• Product Name
  Valsartan & Hydrochlorothiazide Direct Compression (DC) Granules
• Strengths Available
  66.5% - 74% (%w/w) (Customizable per your offering)
• CAS No. / IUPAC Name
  Valsartan:
  CAS: 137862-53-4
  IUPAC: (S)-N-(1-oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
  Hydrochlorothiazide:
  CAS: 58-93-5
  IUPAC: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Molecular Formula / Weight
  Valsartan: C24H29N5O3 / ~435.5 g/mol Hydrochlorothiazide: C7H8ClN3O4S2 / ~297.74 g/mol
• Identification
  Validated HPLC method as per USP / BP / EP pharmacopeial standards
• Release Type
  Immediate Release (IR) formulation suitable for direct compression into tablets for effective and rapid antihypertensive action
• Applications
  Used in combination therapy for the treatment of essential hypertension, especially in patients who are not adequately controlled with monotherapy. Valsartan (ARB) lowers blood pressure by blocking angiotensin II, while Hydrochlorothiazide (thiazide diuretic) reduces fluid volume, enhancing antihypertensive efficacy.
• Storage Conditions
  Store in a tightly closed container, protected from moisture, direct sunlight, and excessive heat.
  Recommended storage temperature: 15°C – 25°C (controlled room temperature).

Valsartan & Hydrochlorothiazide DC Granules – Typical Composition

Why Choose Granules from Salius Pharma?

Outsourcing DC Granules through a trusted partner like Salius Pharma can be a strategic decision to save both time and resources, without compromise on quality or compliance.
Instead, partnering with Salius Pharma—a leading distributor aligned with USFDA-approved and WHO-GMP-certified manufacturers in India—allows you to leverage high-quality products, seamless logistics, and professional support under one roof.

Key Advantages of Partnering with Salius Pharma

• Cost-Efficient Setup
  Avoid heavy capital investment in infrastructure and workforce.
• Guaranteed Quality Assurance
  Products are sourced only from certified facilities with validated processes.
• Access to Advanced Technology
  Benefit from the latest drug delivery systems without managing the tech in-house.
• Accelerated Market Entry
  Launch products faster and establish your brand in less time.
• Custom Formulation Support
  Flexibility to offer tailored pellet solutions as per your market needs.

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times may vary depending on destination, order volume, and regulatory requirements.