Active Pharmaceutical Ingredients
Esomeprazole EC Pellets: A proton pump inhibitor (PPI) that reduces gastric acid secretion by inhibiting the H+/K+ ATPase pump in stomach parietal cells. Enteric coating ensures stability in the gastric environment and targeted release in the intestine. Domperidone SR Pellets: A dopamine antagonist with prokinetic and antiemetic properties. Sustained release formulation provides longer duration of action, enhancing gastrointestinal motility and reducing nausea/vomiting.
| Component | Function |
|---|---|
| Esomeprazole Magnesium Trihydrate + Domperidone | Active Pharmaceutical Ingredient (API) – Proton Pump Inhibitor + Prokinetic / Antiemetic |
| Sugar Spheres / MCC Spheres | Inert core or starter pellets |
| Hydroxypropyl Methylcellulose (HPMC) | Binder / Film former during layering |
| Talc / Colloidal Silicon Dioxide | Anti-adherent / Glidant |
| Eudragit L30D-55 or Eudragit S100 | Enteric coating polymer – protects API from gastric acid, ensures intestinal release (pH > 5.5) |
| Ethyl Cellulose / HPMC K100M | Sustained Release (SR) polymer – controls drug release over time |
| Triethyl Citrate / PEG 6000 | Plasticizer (for polymer coating) |
| Purified Water | Solvent (removed after processing) |
Outsourcing pellets through a trusted partner like Salius Pharma can be a strategic decision to save both time and resources, without compromising on quality or compliance. Instead, partnering with Salius Pharma—a leading distributor aligned with USFDA-approved and WHO-GMP-certified manufacturers in India—allows you to leverage high-quality products, seamless logistics, and professional support under one roof.
We ensure prompt and reliable shipping worldwide. Delivery times may vary depending on destination, order volume, and regulatory requirements.
Looking to source Esomeprazole EC Pellets + Domperidone SR Pellets or other high-quality pharmaceutical pellet formulations?
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Any patented products are excluded from our offerings in regions where such patents are currently in force.
Esomeprazole controls acid secretion while Domperidone enhances gastric motility, offering comprehensive management of GERD and related disorders.
Yes, pellets can be filled into hard gelatin capsules or sachets depending on market demand.
It is mainly used in GERD, functional dyspepsia, peptic ulcer disease, acid reflux with delayed gastric emptying, and reflux-associated nausea/vomiting.
Yes, for regulatory submissions, bioequivalence studies are generally required to demonstrate therapeutic equivalence with reference formulations.